germline allele origin [GENO_0000888]

Describes an allele that is inherited from a parent in virtue of the allele being present in one or both of the parent’s germ cells (sperm or egg). We distinguish germline, somatic, and de novo allele origin based on a combination two key criteria - whether the allele inherited from a parent, and whether it is *heritble' by offspring. Germline variants are both inherited (passed down from a parent) and heritable (passable down to offspring). By contrast, somatic variants are neither inherited or heritable - having originated via a spontaneous mutation in a non-germ cell. De novo mutations in germ cells are not inherited but are typically heritable, as they originated through a spontaneous mutation that made them present a germ cells.

Open germline allele origin in VFB

VFB Term Json

{
    "term": {
        "core": {
            "iri": "http://purl.obolibrary.org/obo/GENO_0000888",
            "symbol": "",
            "types": [
                "Entity",
                "Class"
            ],
            "short_form": "GENO_0000888",
            "label": "germline allele origin"
        },
        "description": [
            "Describes an allele that is inherited from a parent in virtue of the allele being present in one or both of the parent's germ cells (sperm or egg)."
        ],
        "comment": [
            "We distinguish germline, somatic, and de novo allele origin based on a combination two key criteria - whether the allele *inherited* from a parent, and whether it is *heritble' by offspring. Germline variants are both *inherited* (passed down from a parent) and *heritable* (passable down to offspring).  By contrast, somatic variants are neither inherited or heritable - having originated via a spontaneous mutation in a non-germ cell.  De novo mutations in germ cells are not inherited but are typically heritable, as they originated through a spontaneous mutation that made them present a germ cells."
        ]
    },
    "query": "Get JSON for Class",
    "version": "44725ae",
    "parents": [
        {
            "symbol": "",
            "iri": "http://purl.obolibrary.org/obo/GENO_0000877",
            "types": [
                "Entity",
                "Class"
            ],
            "short_form": "GENO_0000877",
            "label": "allele origin"
        }
    ],
    "relationships": [],
    "xrefs": [],
    "anatomy_channel_image": [],
    "pub_syn": [],
    "def_pubs": [
        {
            "core": {
                "symbol": "",
                "iri": "http://flybase.org/reports/Unattributed",
                "types": [
                    "Entity",
                    "Individual",
                    "pub"
                ],
                "short_form": "Unattributed",
                "label": ""
            },
            "FlyBase": "",
            "PubMed": "",
            "DOI": ""
        }
    ]
}