Initiating Methionine

ID: SO_0001582

Class

A codon variant that changes at least one base of the first codon of a transcript.

This is being used to annotate changes to the first codon of a transcript, when the first annotated codon is not to methionine. A variant is predicted to change the first amino acid of a translation irrespective of the fact that the underlying codon is an AUG. As such for transcripts with an incomplete CDS (sequence does not start with an AUG), it is still called.

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Classification

Alternative Names

SynonymScopeReference
initiatior codon variantexact synonym
initiator codon changeexact synonym
VAT:startOverlapexact synonymVAR
Jannovar:initiator_codon_variantexact synonym//doc-openbio.readthedocs.org/projects/jannovar/en/master/var_effects.html
snpEff:NON_SYNONYMOUS_STARTrelated synonymVAR

References