oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity GO_0000703
oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity
ID: GO_0000703
Class
Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site.
Consider also annotating to the molecular function term 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906'.
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Alternative Names
| Synonym | Scope | Reference |
|---|---|---|
| endodeoxyribonuclease III | related synonym | |
| pyrimidine-specific oxidized base lesion DNA N-glycosylase activity | related synonym | |
| endonuclease VIII activity | related synonym | |
| DNA glycosylase/beta-lyase | broad synonym | |
| DNA glycosylase/AP-lyase | broad synonym | |
| bifunctional DNA glycosylase | broad synonym | |
| oxidized pyrimidine base lesion DNA N-glycosylase activity | exact synonym | curators |
| endonuclease III | related synonym |