U3_snoRNA [SO_0001179]

U3 snoRNA is a member of the box C/D class of small nucleolar RNAs. The U3 snoRNA secondary structure is characterised by a small 5’ domain (with boxes A and A’), and a larger 3’ domain (with boxes B, C, C’, and D), the two domains being linked by a single-stranded hinge. Boxes B and C form the B/C motif, which appears to be exclusive to U3 snoRNAs, and boxes C’ and D form the C’/D motif. The latter is functionally similar to the C/D motifs found in other snoRNAs. The 5’ domain and the hinge region act as a pre-rRNA-binding domain. The 3’ domain has conserved protein-binding sites. Both the box B/C and box C’/D motifs are sufficient for nuclear retention of U3 snoRNA. The box C’/D motif is also necessary for nucleolar localization, stability and hypermethylation of U3 snoRNA. Both box B/C and C’/D motifs are involved in specific protein interactions and are necessary for the rRNA processing functions of U3 snoRNA. The definition is most of the old definition for snoRNA (SO:0000275).
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Open U3_snoRNA in VFB

VFB Term Json

{
    "term": {
        "core": {
            "iri": "http://purl.obolibrary.org/obo/SO_0001179",
            "symbol": "",
            "types": [
                "Entity",
                "Class"
            ],
            "short_form": "SO_0001179",
            "label": "U3_snoRNA"
        },
        "description": [
            "U3 snoRNA is a member of the box C/D class of small nucleolar RNAs. The U3 snoRNA secondary structure is characterised by a small 5' domain (with boxes A and A'), and a larger 3' domain (with boxes B, C, C', and D), the two domains being linked by a single-stranded hinge. Boxes B and C form the B/C motif, which appears to be exclusive to U3 snoRNAs, and boxes C' and D form the C'/D motif. The latter is functionally similar to the C/D motifs found in other snoRNAs. The 5' domain and the hinge region act as a pre-rRNA-binding domain. The 3' domain has conserved protein-binding sites. Both the box B/C and box C'/D motifs are sufficient for nuclear retention of U3 snoRNA. The box C'/D motif is also necessary for nucleolar localization, stability and hypermethylation of U3 snoRNA. Both box B/C and C'/D motifs are involved in specific protein interactions and are necessary for the rRNA processing functions of U3 snoRNA."
        ],
        "comment": [
            "The definition is most of the old definition for snoRNA (SO:0000275)."
        ]
    },
    "query": "Get JSON for Class",
    "version": "44725ae",
    "parents": [
        {
            "symbol": "",
            "iri": "http://purl.obolibrary.org/obo/SO_0000593",
            "types": [
                "Entity",
                "Class"
            ],
            "short_form": "SO_0000593",
            "label": "C_D_box_snoRNA"
        }
    ],
    "relationships": [],
    "xrefs": [],
    "anatomy_channel_image": [],
    "pub_syn": [
        {
            "synonym": {
                "scope": "has_exact_synonym",
                "label": "snoRNA U3",
                "type": ""
            },
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            }
        },
        {
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        },
        {
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        },
        {
            "synonym": {
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                "label": "U3 small nucleolar RNA",
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}