neuroblast NB3-3 [FBbt_00001422]

neuroblast NB3-3

ID: FBbt_00001422

Neuroblast that delaminates predominantly at S4 (Schmid et al., 1999). Its first embryonic division produces a ganglion mother cell, which generates a motor neuron (Baumgardt et al., 2014; Wang et al., 2022). Subsequent divisions are type 0, self-renewing and directly producing EL neurons as a Notch OFF hemilineage (Baumgardt et al., 2014; Wang et al., 2022). In the embryo, one of these neuroblasts can be found in each hemisegment from S2-A9 (Birkholz et al., 2013; Urbach et al., 2016). In the larva, it resumes proliferation in all thoracic segments (Lacin and Truman, 2016). The neurons that develop from this neuroblast after larval hatching form postembryonic lineage 8 (Lacin and Truman, 2016).

Birkholz et al. (2015) suggest that NB3-3 generates postembryonic lineage 13 and NB2-4 generates postembryonic lineage 8, but Lacin and Truman (2016) provide lineage tracing and marker data showing that NB3-3 generates lineage 8.