neuroblast NB4-2 [FBbt_00001389]

neuroblast NB4-2

ID: FBbt_00001389

Neuroblast that delaminates at S2 in the intermediate column and, in thoracic and abdominal segments, produces the RP2 motorneuron, which innervates muscles 2, 9 and 11, and the cousin of RP2 motorneuron (CoR), which innervates muscles 26, 27 and 29 (Schmid et al., 1999; Birkholz et al., 2013). It also generates around 19 interneurons (Schmid et al., 1999). In the embryo, one of these cells can be found in each hemisegment from S1-A9 (Birkholz et al., 2013; Urbach et al., 2016). In the larva, it resumes proliferation in all thoracic segments (Lacin and Truman, 2016). The neurons that develop from this neuroblast after larval hatching form postembryonic lineage 13 (Lacin and Truman, 2016).

Birkholz et al. (2015) suggest that NB4-2 generates postembryonic lineage 7 and NB3-3 generates postembryonic lineage 13, but Lacin and Truman (2016) provide lineage tracing and marker data showing that NB4-2 generates lineage 13.